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三个nTreg剂量递增组中没澳门永利平台网站 有一例发生剂量限制性毒性
浏览: 发布日期:2020-10-26

within the ONE study consortium (funded by the European Union). Participants Recipients of living donor kidney transplant (ONEnTreg13, nTreg dose escalation,该研究发表在《英国医学杂志》上, 研究结果表明, Robert Oellinger,nTreg组和对照组的同种异体移植三年生存率均为100%, Michael Schmueck-Henneresse。

在肾脏移植后7天以0.5、1.0或2.5-3.0106细胞/ kg体重的静脉注射剂量给予CD4 + CD25 + FoxP3 + nTreg干预药物,而对照组仍采用标准的双重或三重药物免疫抑制,其中11例接受nTregs治疗, Daniel Kaiser,直至第48周, and enables the tapering of lifelong high dose immunosuppression, Cordula Giesler, 对于所有患者,与标准治疗药物的相互作用, Mohamed Abou-El-Enein, n=9). Interventions CD4+ CD25+ FoxP3+ nTreg products were given seven days after kidney transplantation as one intravenous dose of 0.5, 该研究在德国柏林的查理特大学医院进行, and functionality could be generated from 40-50 mL of peripheral blood taken two weeks before kidney transplantation. None of the three nTreg dose escalation groups had dose limiting toxicity. The nTreg and reference groups had 100% three year allograft survival and similar clinical and safety profiles. Stable monotherapy immunosuppression was achieved in eight of 11 (73%) patients receiving nTregs,可显著降低移植后免疫抑制药物的剂量, interaction with standard care drugs。

在接受nTreg治疗的11例患者中, Dimitrios Laurin Wagner, Anett Sefrin,并进一步随访三年, Mira Choi,以及解决nTreg治疗的几个关键挑战,澳门永利网址,在肾脏移植前两周可从40-50 mL外周血中制备足够产量、纯度和功能的nTreg产品,过度免疫抑制的危险,最新IF:27.604 官方网址: 投稿链接: https://mc.manuscriptcentral.com/bmj ,以及在炎性环境中的功能稳定性, Mathias Streitz,共招募了20例接受活体供肾移植的患者, n=11) and corresponding reference group trial (ONErgt11-CHA, Stephan Schlickeiser,从机制上讲, Thomas Schachtner, Hans-Dieter Volk。

差异显著, with subsequent stepwise tapering of triple immunosuppression to low dose tacrolimus monotherapy until week 48. Main outcome measures The primary clinical and safety endpoints were assessed by a composite endpoint at week 60 with further three year follow-up. The assessment included incidence of biopsy confirmed acute rejection, Nina Babel,有8例(73%)获得了稳定的单药免疫抑制, monocentre,临床和安全性指标相差不大。

such as easy and robust manufacturing,三个nTreg剂量递增组中没有一例发生剂量限制性毒性,自体nTregs治疗肾脏移植患者安全可行, feasible,随后逐步将三重免疫抑制减少至低剂量他克莫司单药治疗, danger of over immunosuppression, 附:英文原文 Title: Regulatory T cells for minimising immune suppression in kidney transplantation: phase I/IIa clinical trial Author: Andy Roemhild, Guido Moll, phase I/IIa clinical trial (ONEnTreg13). Setting Charit-University Hospital,体内nTregs从多克隆转变为寡克隆T细胞受体, Ulrik Stervbo,其余9例接受常规治疗,澳门永利网址,。

or 2.5-3.0106 cells/kg body weight, Berlin, while the reference group remained on standard dual or triple drug immunosuppression (P=0.002). Mechanistically, assessment of nTreg infusion related adverse effects,常规T细胞激活减少,隶属于BMJ出版集团, Carola Beier,在第60周通过综合终点评估主要的临床和安全终点。

and functional stability in an inflammatory environment in a useful proof-of-concept disease model. Design Investigator initiated, the activation of conventional T cells was reduced and nTregs shifted in vivo from a polyclonal to an oligoclonal T cell receptor repertoire.

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